Rossoll Lab

The Rossoll Lab at the Department of Neuroscience at the Mayo Clinic in Florida

Postdoc positions in Neurodegenerative Disease Research (ALS, SMA) are available in the lab of Dr. Wilfried Rossoll at the Department of Neuroscience at Mayo Clinic in Jacksonville, Florida (starting January 2017).

2018

Khalil B, Morderer D, Price PL, Liu F, Rossoll W. mRNP assembly, axonal transport, and local translation in neurodegenerative diseases. Brain Res. 2018 Feb 17. pii: S0006-8993(18)30082-9. doi: 10.1016/j.brainres.2018.02.018. [Epub ahead of print] PMID: 29462608

Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, Cairns NJ, Boylan KB, Dickson DW, Rademakers R, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC, Glass JD, Rossoll W. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nat Neurosci. 2018 Feb;21(2):228-239. doi: 10.1038/s41593-017-0047-3. Epub 2018 Jan 8. PMID: 29311743

Nature Neuroscience, volume 21, issue 2, table of contents

2017

Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028.

Donlin-Asp PG, Rossoll W, Bassell GJ. Spatially and temporally regulating translation via mRNA binding proteins in cellular and neuronal function. FEBS Lett. 2017 Mar 10. doi: 10.1002/1873-3468.12621. Review. PMID: 28295262

Donlin-Asp PG, Fallini C, Campos J, Chou CC, Merritt ME, Phan HC, Bassell GJ, Rossoll W. The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Cell Reports. 2017 Feb 14;18(7):1660-1673. doi: 10.1016/j.celrep.2017.01.059. PMID: 28199839

2016

Wang ET, Taliaferro JM, Lee JA, Sudhakaran IP, Rossoll W, Gross C, Moss KR, Bassell GJ. Dysregulation of mRNA Localization and Translation in Genetic Disease. J Neurosci. 2016 Nov 9;36(45):11418-11426. PMID: 27911744

Preininger MK, Jha R, Maxwell JT, Wu Q, Singh M, Wang B, Dalal A, Mceachin ZT, Rossoll W, Hales CM, Fischbach PS, Wagner MB, Xu C. A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses. Dis Model Mech. 2016 Sep 1;9(9):927-39. doi: 10.1242/dmm.026823. PubMed PMID: 27491078; PubMed Central PMCID: PMC5047684.

Donlin-Asp PG, Bassell GJ, Rossoll W. A role for the survival of motor neuron protein in mRNP assembly and transport. Curr Opin Neurobiol. 2016 Aug;39:53-61. doi: 10.1016/j.conb.2016.04.004. Epub 2016 Apr 29. Review. PubMed PMID: 27131421. (cover article)

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3. PubMed PMID: 27341800; PubMed Central PMCID: PMC4919863.

Fallini C, Donlin-Asp PG, Rouanet JP, Bassell GJ, Rossoll W. Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons. J Neurosci. 2016 Mar 30;36(13):3811-20. doi: 10.1523/JNEUROSCI.2396-15.2016. PubMed PMID: 27030765; PubMed Central PMCID: PMC4812137. (cover article)

2000 - 2015

Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Hum Mol Genet. 2015 Sep 15;24(18):5154-73. doi: 10.1093/hmg/ddv238. Epub 2015 Jun 30. PubMed PMID: 26130692; PubMed Central PMCID: PMC4550816.

Fallini C, Rouanet JP, Donlin-Asp PG, Guo P, Zhang H, Singer RH, Rossoll W, Bassell GJ. Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons. Dev Neurobiol. 2014 Mar;74(3):319-32. doi: 10.1002/dneu.22111. Epub 2013 Oct 4. PubMed PMID: 23897586; PubMed Central PMCID: PMC3906212. (* co-corresponding author)

Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Drory VE, Brown RH Jr, Landers JE. Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis. Nature. 2012 Aug 23;488(7412):499-503. doi: 10.1038/nature11280. PubMed PMID: 22801503; PubMed Central PMCID: PMC3575525.

Fallini C, Bassell GJ, Rossoll W. The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Hum Mol Genet. 2012 Aug 15;21(16):3703-18. doi: 10.1093/hmg/dds205. Epub 2012 May 28. PubMed PMID: 22641816; PubMed Central PMCID: PMC3406762. (cover article)

Fallini C, Bassell GJ, Rossoll W. Spinal muscular atrophy: the role of SMN in axonal mRNA regulation. Brain Res. 2012 Jun 26;1462:81-92. doi: 10.1016/j.brainres.2012.01.044. Epub 2012 Jan 28. Review. PubMed PMID: 22330725; PubMed Central PMCID: PMC3360984.

Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT. Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. PLoS One. 2012;7(6):e38658. doi: 10.1371/journal.pone.0038658. Epub 2012 Jun 21. PubMed PMID: 22761693; PubMed Central PMCID: PMC3380899.

Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet. 2011 May 1;20(9):1701-11. doi: 10.1093/hmg/ddr046. Epub 2011 Feb 7. PubMed PMID: 21300694; PubMed Central PMCID: PMC3071668.

Fallini C, Zhang H, Su Y, Silani V, Singer RH, Rossoll W, Bassell GJ. The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. J Neurosci. 2011 Mar 9;31(10):3914-25. doi: 10.1523/JNEUROSCI.3631-10.2011. PubMed PMID: 21389246; PubMed Central PMCID: PMC3070748. (* co-corresponding author; "This week in the Journal" and cover article.)

Glinka M, Herrmann T, Funk N, Havlicek S, Rossoll W, Winkler C, Sendtner M. The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons. Hum Mol Genet. 2010 May 15;19(10):1951-66. doi: 10.1093/hmg/ddq073. Epub 2010 Feb 18. PubMed PMID: 20167579.

Fallini C, Bassell GJ, Rossoll W. High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function. Mol Neurodegener. 2010 Apr 21;5:17. doi: 10.1186/1750-1326-5-17. PubMed PMID: 20406490; PubMed Central PMCID: PMC2867961. ('Highly accessed', featured in ‘The ALS Forum’)

Rossoll W, Bassell GJ. Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes. Results Probl Cell Differ. 2009;48:289-326. doi: 10.1007/400_2009_4. PubMed PMID: 19343312; PubMed Central PMCID: PMC3718852.

Oprea GE, Kröber S, McWhorter ML, Rossoll W, Müller S, Krawczak M, Bassell GJ, Beattie CE, Wirth B. Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy. Science. 2008 Apr 25;320(5875):524-7. doi: 10.1126/science.1155085. PubMed PMID: 18440926; PubMed Central PMCID: PMC4908855.

Zhang H, Xing L, Rossoll W, Wichterle H, Singer RH, Bassell GJ. Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. J Neurosci. 2006 Aug 16;26(33):8622-32. PubMed PMID: 16914688; PubMed Central PMCID: PMC4956918.

Ito Y, Wiese S, Funk N, Chittka A, Rossoll W, Bömmel H, Watabe K, Wegner M, Sendtner M. Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7871-6. Epub 2006 May 9. PubMed PMID: 16684879; PubMed Central PMCID: PMC1472537.

Götz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat Neurosci. 2005 Sep;8(9):1169-78. Epub 2005 Aug 21. PubMed PMID: 16116448; PubMed Central PMCID: PMC1361767.

Grohmann K, Rossoll W, Kobsar I, Holtmann B, Jablonka S, Wessig C, Stoltenburg-Didinger G, Fischer U, Hübner C, Martini R, Sendtner M. Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1). Hum Mol Genet. 2004 Sep 15;13(18):2031-42. Epub 2004 Jul 21. PubMed PMID: 15269181.

Rossoll W, Jablonka S, Andreassi C, Kröning AK, Karle K, Monani UR, Sendtner M. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons. J Cell Biol. 2003 Nov 24;163(4):801-12. Epub 2003 Nov 17. PubMed PMID: 14623865; PubMed Central PMCID: PMC2173668. (News - In This Issue)

Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M. Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. J Cell Biol. 2002 Nov 25;159(4):563-9. PubMed PMID: 12446740; PubMed Central PMCID: PMC2173089.

Jablonka S, Holtmann B, Meister G, Bandilla M, Rossoll W, Fischer U, Sendtner M. Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10126-31. Epub 2002 Jun 28. PubMed PMID: 12091709; PubMed Central PMCID: PMC126635.

Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M. Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? Hum Mol Genet. 2002 Jan 1;11(1):93-105. PubMed PMID: 11773003. (cover article).

Jablonka S, Rossoll W, Schrank B, Sendtner M. The role of SMN in spinal muscular atrophy. J Neurol. 2000 Mar;247 Suppl 1:I37-42. Review. PubMed PMID: 10795885.

Monani UR, Sendtner M, Coovert DD, Parsons DW, Andreassi C, Le TT, Jablonka S, Schrank B, Rossoll W, Prior TW, Morris GE, Burghes AH. The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12;9(3):333-9. Erratum in: Hum Mol Genet. 2007 Nov 1;16(21):2648. Rossol, W [corrected to Rossoll, W]. PubMed PMID: 10655541.

Jablonka S, Schrank B, Kralewski M, Rossoll W, Sendtner M. Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type III. Hum Mol Genet. 2000 Feb 12;9(3):341-6. PubMed PMID: 10655542.